Friday, August 31, 2012

Abelard Construction Wins 2012 Award for Top 30 Roofing ...


Brooklyn Park, MN (PRWEB) August 22, 2012

Abelard Construction won the 2012 Award from Roofing Contractor Magazine for Top 30 Roofing Contractors in the nation. Roofing Contractor Magazines Top 100 list contains companies that have proven that they know what it takes to succeed from year to year.

Were really excited to be awarded the 2012 Top 30 tier of the Top 100 construction companies in the nation. There is a lot of competition out there in this industry, and we strive to remain the best in the business, says Brian Southard, Co-Founder of Abelard Construction.

In spite of industry trends, the economic downturn and the flood of more and more roofing companies coming to the market, Abelard has grown sales and offices this year by remaining ahead of the game and utilizing best practices in the industry. Abelard Construction remains cutting edge in a highly competitive industry by hiring the best in the business, their team of highly trained insurance claim specialists to get the job done right. Abelard excels by using the proprietary Xactimate software program, the same software used by insurance companies, making the claims process fast and efficient. Abelard inspectors personally meet with property owners and insurance adjusters onsite, negotiate claims, and manage all storm related repairs with quality workmanship.

Commitment to customer service, going above and beyond, and helping property owners recover after catastrophic events is our mission and has been for over 15 years. We are very proud of our success and leadership status in the industry, says Abelard Co-Founder Anthony Delmedico.

About Abelard Construction

Abelard Construction is rated by customers as the best in the business. Abelard Construction is the national leader in the residential and commercial restoration and construction industry. With over 15 years of experience as a full-service general contractor in 17 states throughout the nation, Abelard Construction provides a free comprehensive property inspection covering roof, siding, gutters, paint, window damage and works with the insurance claim adjustor to get property owners the repairs they need. As a licensed general contractor, we are able to respond to your unique construction and restoration needs with speed and flexibility. Whether you have a residential roofing emergency, require water, fire, smoke or mold damage restoration or need general contractor services for general maintenance on commercial properties, we are poised to help. Visit http://www.abelardconstruction.com or call 1.888.260.ROOF. Click here for more information on the Storm Inspection Process: http://youtu.be/LPsGTEi3ghQ

About Roofing Contractor Magazine

Roofing Contractor is the premier industry publication written specifically for the contractor. An independent magazine, Roofing Contractor?s bold, concise and timely editorial addresses issues critical to contractors and provides the information and insights that help contractors succeed. Learn more at http://www.roofingcontractor.com

Source: http://freereleasepress.com/abelard-construction-wins-2012-award-for-top-30-roofing-contractor-in-the-nation/

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Motherhood Is A Blessing For Each Lady. The Joy Of Bringing A ...

Motherhood is a blessing for each lady. The joy of bringing a lifestyle in to the globe is unparalleled and can?t be described in phrases. It can only be felt and skilled by a mother who delivers her baby after nurturing it for all those months in her womb. If you are anticipating, you must rejoice this blessed event by wearing stunning maternity clothing.

Maternity clothes are clothes that are created particularly for the anticipating moms to be. These clothing allow pregnant women show off their stunning infant bump, their female body lines and curves instead of hiding them in loose and shapeless clothing.

There are designer maternity clothes accessible in a variety of styles, designs, and patterns to let you look and feel beautiful from inside and outside. You can purchase stylish maternity skirts, cool maternity jeans, attractive maternity swimwear, and elegant maternity gowns, and much more to stay trendy and fashionable in 1 of the most essential stage of your lifestyle.

If you have the right maternity clothes in your wardrobe, you will not shy absent from heading out. Gown yourself smartly and stroll out with fantastic self-confidence and self-esteem. You will receive masses of compliments about your radiant and joyful look and look.

The best part is that the maternity clothing are easily available at off-line and on-line buying centres. Buying stores of repute stock a wide variety of clothes for small, medium-sized, big, and additional-big ladies. Moreover, they have maternity clothing for day-to-day wearing, informal put on, workplace put on, and fancy occasions. Discovering the clothing that best match your physique type, as nicely as your individual needs and requirements easy with such shops.

No matter, exactly where you purchase your maternity clothes from, just maintain in mind that the clothing that you purchase ought to be suitable for the season. If it is winter, purchase warm and divan clothing and for summers, purchase light weight clothing. Make sure that the maternity clothes you buy fit nicely, since restricted clothes can trigger pain and free clothes can often portray a -frumpy look?.

Most great Maternity stores will have a great choice so you will be tempted to purchase a great deal much more than you may have expected ? so make certain you decide your budget initial and then start shopping. Do not more than-invest as you may only be sporting these clothing for a extremely short period of time.

For fashionable maternity clothes at inexpensive costs prices, visit www.glowmaternity.com.au

An Author is a contributor writer for this website and plays a significant role for this site ? Maternity clothes.

for more on plus size maternity clothes and maternity clothes evening wear see our website

Source: http://www.mylife-coach.net/5397/motherhood-is-a-blessing-for-each-lady-the-joy-of-bringing-a-lifestyle-in-to-the-globe-is-unparalleled-and-cant/

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Egypt president in Iran for first visit in decades

TEHRAN, Iran (AP) ? Egypt's President Mohammed Morsi has arrived in Tehran for the first visit by an Egyptian leader to Iran in decades.

Iran's state TV in a live broadcast showed Morsi being received by Tehran's vice president in charge of executive affairs Hamid Baghaei in the capital's Mehrabad airport on Thursday. The Egyptian president is visiting for a summit of the 120-nation Non-Aligned Movement.

Tehran cut diplomatic relations in 1979 because of Egypt's peace accord with Israel. Since the 1979 Islamic revolution, Iran has considered Israel as its arch foe.

Iran's leadership welcomed the 2011 uprising in Egypt that ultimately brought Islamist Morsi to the presidency.

Morsi is supposed to transfer the rotating leadership of the Non-Aligned Movement to Tehran.

Source: http://news.yahoo.com/egypt-president-iran-first-visit-decades-051743542.html

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Surprise! Amazon Runs Out of Kindle Fires

If you're looking to pick up a Kindle Fire from Amazon, you're out of luck. The company announced that they have sold out of Kindle Fires. There are no more. Now Fire fans will have to wait until a new Amazon-branded tablet appears on the market next week. Yeah, a whole week.

Source: http://feedproxy.google.com/~r/GearFactor/~3/LK2OiqphpQI/

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Flight attendant's career landing in Guinness book

HONOLULU (AP) ? A flight attendant is landing in the Guinness World Records book after spending 63 years moving about the cabin.

Ron Akana, 83, worked his last route over the weekend on a United Airlines flight from Denver to Kauai, ending his career in the state where it began.

Hawaii, however, wasn't his final stop. His destination was retirement in Boulder, Colo., where he has been living since 2002 to be closer to his grandchildren. He spent his first few days of retirement writing thank-you notes to well-wishers.

"I wasn't expecting this much attention," he said Tuesday.

Akana joined the airline while a student at the University of Hawaii in 1949, when friends spotted a newspaper ad. "We didn't even know what a flight steward was," he recalled. "But it meant getting to the mainland, which was a huge deal in those days.

"It seemed pretty exciting and it proved to be more than that," he said.

And so he became one of United's first male flight attendants. "We just liked working with girls," he said.

The Korean War took him away from his job for two years when he was drafted in 1951. Akana said his most memorable moments included meeting the cast of the 1953 movie "From Here to Eternity," ? mentioning Frank Sinatra and Deborah Kerr by name ? and going from propeller planes to jets, which cut travel time in half.

Over the years, he's seen it all. Passengers would dress up, not down. Think suits, not flip-flops. Smoking was no big deal, not a federal offense.

Over time, though, things changed. The meal service became better. No more smoke. In-flight movies, which he said started to be shown seven or eight years after he began his career. And, of course, tight security after the Sept. 11 terrorist attacks.

Guinness World Records came calling a few months ago and later sent him a plaque recognizing him as the longest-serving flight attendant. He's been told he'll appear in the record book in October.

To get a sense of how long he's been in the air, consider that if his 200 million miles counted toward United's frequent flyer program, he could treat the entire town of Big Rock, Ill., population 1,138, to a first class trip from Chicago to Honolulu and back ? then once a month for the next 12 years, he'd still have enough miles to travel with his wife, Elizabeth, anywhere they want in the continental U.S.

Akana decided to retire after he was offered a buyout. But he admits being tempted to hang on for the arrival of the next super jet, the Boeing 787. "I shall have to watch from the sidelines," he said.

While he's now retired, Akana is not done flying. From now on, his wife will be joining him.

"I got terrific travel privileges," he said, adding: "There's a lot to be seen."

Source: http://news.yahoo.com/flight-attendants-career-landing-guinness-book-192854042.html

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Thursday, August 30, 2012

Romney: Time to leave disappointments behind

Republican presidential nominee Mitt Romney looks over the podium position during a sound check at the Republican National Convention in Tampa, Fla., on Thursday, Aug. 30, 2012. (AP Photo/J. Scott Applewhite)

Republican presidential nominee Mitt Romney looks over the podium position during a sound check at the Republican National Convention in Tampa, Fla., on Thursday, Aug. 30, 2012. (AP Photo/J. Scott Applewhite)

Republican presidential nominee Mitt Romney and Republican vice presidential nominee, Rep. Paul Ryan pose for a group picture with their campaign staff at the Republican National Convention in Tampa, Fla., on Thursday, Aug. 30, 2012. (AP Photo/Jae C. Hong)

FILE - In this Aug. 26, 2012 file photo, Republican presidential candidate, former Massachusetts Gov. Mitt Romney, and his wife Ann walk to church in Wolfeboro, N.H. On Thursday, Romney will accept his party's presidential nomination. (AP Photo/Evan Vucci, File)

(AP) ? Mitt Romney's mission in this election: connect with Americans on a personal level.

He sought to do so Thursday by appealing to feelings of anxiety ? if not disappointment ? that's rippling through the electorate as the nation faces stubbornly high unemployment and fears about its future place in the world.

"Hope and change had a powerful appeal. But tonight I'd ask a simple question: If you felt that excitement when you voted for Barack Obama, shouldn't you feel that way now that he's President Obama?" Romney will say as he formally accepts the Republican presidential nomination Thursday night, according to prepared remarks. "You know there's something wrong with the kind of job he's done as president when the best feeling you had, was the day you voted for him."

Aides said the speech was the most important of Romney's political career and will forever change his family's legacy. In winning his party's presidential nomination, the former Massachusetts governor has succeeded where his father failed a generation ago. But facing a two-month sprint to an Election Day matchup against President Barack Obama, Romney is now trying to broaden his appeal and connect with women and with middle-of-the road voters who will ultimately decide his fate.

To do so, he is trying to strike a soft tone laced with deeply personal themes. He will draw from his Mormon faith and the influence of his mother and father ? both dead for more than a decade ?when he faces the Republican National Convention and a prime-time audience.

"My mom and dad gave their kids the greatest gift of all ? the gift of unconditional love. They cared deeply about who we would be, and much less about what we would do," Romney will say, according to prepared remarks released by the campaign.

George Romney, a Michigan governor, ran for the Republican presidential nomination in 1968 when Romney was a young man. His mother, Lenore, ran unsuccessfully for the U.S. Senate in Michigan in 1970.

"My mom and dad were true partners, a life lesson that shaped me by everyday example. When my mom ran for the Senate, my dad was there for her every step of the way," Romney said.

The remarks will be delivered on a stage that puts him a little bit closer to the crowd inside the convention hall. His campaign hopes the evening ends with Americans feeling a little bit closer to the Republican presidential candidate, too.

On this night, they are telling Romney's story

The entire evening ? from the physical staging to the speakers' program to the planned whole-family entrance after Romney's big speech ? is aimed at introducing the sometimes stiff and distant politician as a businessman, Olympic savior and deeply religious family man. His pitch to his party, as well as to the many undecided voters who are disappointed in the country's direction, will be that he's the candidate better able to shoulder the country's economic burdens.

"To the majority of Americans who now believe that the future will not be better than the past, I can guarantee you this: If Barack Obama is re-elected, you will be right," Romney will say.

Romney's speech is the centerpiece of the evening, and will touch on themes that are both personal and political. He'll tell stories, aides say, that haven't been part of his campaign trail pitch. He'll discuss his Mormon faith, particularly his time helping struggling families when he served as a church leader in Boston.

"Like a lot of families in a new place with no family, we found kinship with a wide circle of friends through our church," he will say. "We prayed together, our kids played together and we always stood ready to help each other out in different ways."

To prepare for the big night, Romney has spent months making meticulous notes about his experiences campaigning. He's read numerous previous convention speeches and talked to a number of close friends and confidants about how to approach his address. He and his wife, Ann, spent part of last weekend rehearsing their speeches in an auditorium at Brewster Academy in Wolfeboro, N.H., near the family's lakeside summer home.

When the big moment comes, he'll be standing in the Tampa Bay Times Forum on a stage that organizers rebuilt overnight. They replaced what had been a standard stage at the front of the hall with a section that pushes the podium toward the center of the floor, so Romney will physically stand among the crowd as he speaks.

"It brings him a little bit closer," campaign manager Matt Rhoades said of the new arrangement.

Before Romney speaks, a parade of people from his past will take to the podium to walk through different phases of his life: his time running the private equity firm Bain Capital, his years running the 2002 Winter Olympics in Salt Lake City and his experiences as governor of Massachusetts. Referred to inside the campaign as "character witnesses," the speeches are designed to showcase the man who friends say inspires fierce loyalty. Much of the list was drawn up by Romney's son Tagg, who found acquaintances from their Mormon church in Massachusetts to talk about how his father helped them get by.

Among those set to address the crowd are Bob White, a longtime friend and colleague from Bain Capital, and Tom Stemberg, the founder of Staples, the office supply store; Olympic speed skater Derek Parra and hockey player Mike Eruzione; and former Massachusetts Lt. Gov. Kerry Healey, who is still a closer adviser.

Shortly before 10 p.m. Eastern time, organizers will run a film showcasing Romney's life. A handful of young video staffers have spent weeks working 16-hour days inside a suite at the Marriott hotel where Romney is now staying, editing the piece through the wee hours of the morning.

Then, it will be Romney's turn. When the speech is over, he'll walk back up the stage to where his entire family ? wife, five sons and their wives, and 15 of his 18 grandchildren ? will be waiting. Thousands of balloons nestled in netting high above the convention floor will drop, carefully positioned so that none fall on the family.

It will create the image his campaign is looking for. At that Marriott hotel the morning of the speech, Rhoades saw a copy of Thursday's Tampa Bay Times, where, on the front page, running mate Paul Ryan and his family are pictured waving after his Wednesday night address, the vice presidential nominee's arm wrapped around the waist of his wife, Janna.

Rhoades pointed at the photo.

"We need that," he said.

___

Associated Press writer Julie Mazziotta contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-08-30-Romney/id-2ca48da2d19141f7a6f95d012ff238a3

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Tuesday, August 28, 2012

Total Vibration ? Blog Archive ? General Insurance coverage ...

Locating valid guidance about insurance plan is difficult amongst each of the suggestions on the web. Don?t feel all you study. Do your own analysis before buying any insurance plan. This short article must direct you with your choices.

If at all possible you should try to bundle all of your policies with each other to save cash. Shopping for several insurance policies through the very same representative could save you hundreds, and even countless numbers, of bucks over the course of a year. Lots of the best insurers will offer savings in the event you bundle your guidelines together.

You may assist make sure your insurance policy declare proceeds efficiently by keeping whole documentation and data from the complete procedure. Come up with a document of most communications along with your insurance plan supplier, whilst keeping a historical and recorded timeline in your claim?s advancement. Always deliver a letter asking for a written confirmation following speaking to somebody on the phone.

In case you are a tobacco user, quitting right away will help decrease the price of health and life insurance. Cigarette smokers spend significantly better prices for insurance since smoking cigarettes is really bad. When you can go cigarettes-free of charge, next time you renew your insurance policy, you can almost certainly get lower prices.

Explain just what took place to aid your insurance take care of your claim. You should take images for any damaged home. Never form a story and worsen the damages in the make an effort to make more cash: you can get in severe trouble just for this rather than get paid by any means.

Make sure you have any estimate you are able to by yourself. When you have to file a declare, ensure you make use of dependable places for your estimates. Don?t ever depend on insurance carrier associates. You ought to use your very own estimator. If your insurance plan company?s agent gives an estimate before you?ve got the opportunity to obtain your very own, don?t let this hold you back from doing so.

When you are working a small company, you should make sure that all of your current insurance plan choices are included. Shop around for an insurance policy that handles all hazards linked to your kind of organization.

Although getting insurance plan can be quite a complicated method, it is actually definitely some thing you cannot do without the need of. Keep to the ideas offered here to get the best rates and coverage you will need. Whether you are choosing a new plan or evaluating a classic 1, start by composing downwards a long list of your insurance plan requires.

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Source: http://blog.thorsrubberhammer.com/2012/08/general-insurance-coverage-assistance-and-strategies-for-you-2/

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Regulatory Career Connections: Quality/Risk Management jobs ...

Dassault Syst?mes, the 3D Experience Company, provides business and people with virtual universes to imagine sustainable innovations. Its world-leading solutions transform the way products are designed, produced, and supported. Dassault Syst?mes? collaborative solutions foster social innovation, expanding possibilities for the virtual world to improve the real world. The group brings value to over 150,000 customers of all sizes, in all industries, in more than 80 countries. For more information, visit www.3ds.com. CATIA, SolidWorks, ENOVIA, SIMULIA, DELMIA, 3D VIA, 3DSwYm, EXALEAD and Netvibes are registered trademarks of Dassault Syst?mes or its subsidiaries in the US and/or other countries.

To strength and accelerate our Life Sciences Industry expansion, Dassault Syst?mes (3DS) is looking for a Business Consultant Director H/F experienced in Pharmaceutical Regulatory Affairs.

You are the Life Sciences Regulatory Affairs reference for our customers as well as internally at 3DS. You contribute actively to the 3DS Life Sciences worldwide strategy.

You are the inspirer of the VP Industry leader to position and promote our Life Sciences Experience Platform for Regulatory Affairs. Interacting with our customers, you also represent 3DS in key Regulatory Affairs events and associations.

You have a deep experience of the Life Sciences Industry and its regulatory processes, gained at a National/International Regulatory Agency (FDA, EMA, ANSM?) or in a pharmaceutical company, as Regulatory Affairs expert.

Following a minimum 5 years experience where you directly participated to a global drug submission, you are familiar with industry lifecycle (IND, IMPD, NDA, CP, DCP, MRP, NP, PSURs) and associated business processes like product variations and packaging.

Interactions with regulatory bodies are your day to day activities. You have detailed knowledge of EU/US/JP regulations and guidelines on drug development and submissions both pre and post approval. You are familiar with on-going process digitalization (eCTD, electronic transmission?). Your knowledge in related domains like Pharmacovigilance, Medical Device processes or GxP is a plus. Your core skills in Pharmaceutical segment allow you to well understand the focus and the challenges of our clients. Dassault Syst?mes offers you the power of its collaborative innovation platform allowing global teams collaboration through the enterprise ecosystem, directly supporting the ongoing pharmaceutical market (r)evolution. Guiding our platform evolution to match strategic pharmaceutical Regulatory Affairs current and future expectations will be your target.

Source: http://regulatorycareers.raps.org/jobs/4893288/business-consultant-director-lifesciences-specialized-in-regulatory-affairs-h-f

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Monday, August 27, 2012

Lendthing Keeps Track of Who's Borrowed What and Helps You Get It Back [Borrowing]

Lendthing Keeps Track of Who's Borrowed What and Helps You Get It BackiOS: We all have a few friends with whom we borrow and lend lots of stuff, but it can get hard to keep track of it all. Lendthing is a simple app that keeps track of who has what, and even lets you send SMS reminders to help get everything back.

Lendthing is easy: just hit the big plus button to add a new item, note who you lent it to (or who borrowed it from you), and it'll keep a running list of who has what. You can tap on an item to mark it returned, or send that person a pre-written SMS reminder to give or get the item in question back. If they're in your contacts, it'll automatically grab their number for you.

It's handy for those of us that lend and borrow like crazy, but we'd love to see other features come to the app?for example, being able to set a location-based reminder would be awesome, so you can remember to get your stuff back the next time you visit. Overall, though, it's a simple way to keep track of where all your stuff is.

Lendthing is a $1.99 download for iOS only.

Lendthing | iTunes App Store

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/ABsjfxQSI9Q/lendthing-keeps-track-of-whos-borrowed-what-and-helps-you-get-it-back

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pH-sensitive liposomal cisplatin improves peritoneal carcinomatosis treatment without side-effects

pH-sensitive liposomal cisplatin improves peritoneal carcinomatosis treatment without side-effects [ Back to EurekAlert! ] Public release date: 27-Aug-2012
[ | E-mail | Share Share ]

Contact: Andrea Teixeira Carvalho
atcteixeira@gmail.com
Society for Experimental Biology and Medicine

Scientists at the Oswaldo Cruz Foundation and Federal University of Minas Gerais, led by Dr. Andra Teixeira-Carvalho and Dr. Mnica Cristina de Oliveira, have developed and characterized a circulating and pH-sensitive liposome containing cisplatin (SpHL-CDDP) aiming to promote the release of cisplatin near the tumor as well as decreasing toxicity. The development of analog drugs and new formulations are current strategies for increasing the effectiveness and safety of cisplatin as an anti-peritoneal carcinomatosis drug. The results, which appear in the August 2012 issue of Experimental Biology and Medicine demonstrate that the treatment of initial or disseminated Ehrlich ascitic tumor-bearing Swiss mice with SpHL-CDDP improved the antitumor efficacy and decreased renal and bone marrow toxicity of cisplatin-based therapy.

"Peritoneal carcinomatosis is a serious concern in the treatment of abdominal tumors such as hepatic, gastric and gynecological tumors", says Dr. Oliveira. "The strategy of local chemotherapy is interesting due to the possibility to increase the therapeutic efficacy while minimizing systemic side-effects. SpHL-CDDP treatment was able to reduce cancer cell proliferation and increase survival, in the animal model, with no known toxicity clinical signs found in the free CDDP treatment." says Dr. Maroni.

These results open the possibility of future use of SpHL-CDDP in chemotherapy of peritoneal carcinomatosis. "New studies are underway in our research group to investigate the signaling pathways of cell death as well as use of high doses of SpHL-CDDP for the treatment of peritoneal carcinomatosis", says Dr. Teixeira-Carvalho.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said " This very interesting study has utilized a new pH-sensitive circulating liposome containing cisplatin formulation which decreased cancer proliferation and drug toxicity in a mouse model. This provides the basis for further translational testing of this formulation leading to clinical trials aimed at more effective treatment of abdominal tumors".

###

Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903.

Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit www.sebm.org. If you are interested in publishing in the journal please visit http://ebm.rsmjournals.com .


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


pH-sensitive liposomal cisplatin improves peritoneal carcinomatosis treatment without side-effects [ Back to EurekAlert! ] Public release date: 27-Aug-2012
[ | E-mail | Share Share ]

Contact: Andrea Teixeira Carvalho
atcteixeira@gmail.com
Society for Experimental Biology and Medicine

Scientists at the Oswaldo Cruz Foundation and Federal University of Minas Gerais, led by Dr. Andra Teixeira-Carvalho and Dr. Mnica Cristina de Oliveira, have developed and characterized a circulating and pH-sensitive liposome containing cisplatin (SpHL-CDDP) aiming to promote the release of cisplatin near the tumor as well as decreasing toxicity. The development of analog drugs and new formulations are current strategies for increasing the effectiveness and safety of cisplatin as an anti-peritoneal carcinomatosis drug. The results, which appear in the August 2012 issue of Experimental Biology and Medicine demonstrate that the treatment of initial or disseminated Ehrlich ascitic tumor-bearing Swiss mice with SpHL-CDDP improved the antitumor efficacy and decreased renal and bone marrow toxicity of cisplatin-based therapy.

"Peritoneal carcinomatosis is a serious concern in the treatment of abdominal tumors such as hepatic, gastric and gynecological tumors", says Dr. Oliveira. "The strategy of local chemotherapy is interesting due to the possibility to increase the therapeutic efficacy while minimizing systemic side-effects. SpHL-CDDP treatment was able to reduce cancer cell proliferation and increase survival, in the animal model, with no known toxicity clinical signs found in the free CDDP treatment." says Dr. Maroni.

These results open the possibility of future use of SpHL-CDDP in chemotherapy of peritoneal carcinomatosis. "New studies are underway in our research group to investigate the signaling pathways of cell death as well as use of high doses of SpHL-CDDP for the treatment of peritoneal carcinomatosis", says Dr. Teixeira-Carvalho.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said " This very interesting study has utilized a new pH-sensitive circulating liposome containing cisplatin formulation which decreased cancer proliferation and drug toxicity in a mouse model. This provides the basis for further translational testing of this formulation leading to clinical trials aimed at more effective treatment of abdominal tumors".

###

Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903.

Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit www.sebm.org. If you are interested in publishing in the journal please visit http://ebm.rsmjournals.com .


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-08/sfeb-plc082712.php

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Did Taliban behead 17 people for dancing? Maybe not.

Initial reports said 17 people were beheaded by the Taliban for dancing and singing. Taliban leaders fighting over two women triggered the killings, says a provincial official.

By Heidi Vogt and Mirwais Khan,?Associated Press / August 27, 2012

Members from the "District Unknown" heavy metal band walk with their musical instruments outside a classroom in Kabul in June. Kabul's rock music school, which opened in May, reflects the return, although sometimes tentative, of social and individual freedoms since the end of the Taliban rule in 2001.

REUTERS/Omar Sobhani

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?Insurgents attacked a large party in a Taliban-controlled area of southern Afghanistan and beheaded 17 people, officials said on Monday.

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The head of the local government initially said the victims were civilians at a celebration late Sunday involving music and dancing in the Musa Qala district of Helmand province. The official, Neyamatullah Khan, said the Taliban killed the party-goers for flouting the extreme brand of Islam embraced by the militants.

But a provincial government official said later that those killed were caught up in a fight between two Taliban commanders over two women, who were among the dead. Daoud Ahmadi, a spokesman for the provincial government, said shooting broke out during the fight. He said it was unclear whether the music and dancing triggered the violence and whether the dead were all civilians or possibly included some fighters.

RECOMMENDED: How well do you know Afghanistan? Take the quiz

Ahmadi said all of the bodies were decapitated but it was not clear if they had been shot first.

In other violence, two American soldiers were shot and killed by one of their Afghan colleagues in the east, military officials said. Afghan officials said the killings appeared to be accidental, however NATO would not comment on the question of whether the killings were intentional or accidental.

The Taliban has controlled large parts of the district of Musa Qala, an area encompassing more than 100 villages, since 2001. They enforce the same strict interpretation of Islamic law that was imposed on all of Afghanistan during Taliban rule of Afghanistan from 1996-2001.

U.S. Marines have battled the Taliban for years in Musa Qala, but the insurgent group still wields in significant power in the area as international forces across the country draw down and hand over control to Afghan forces. Helmand province, where Musa Qala is located, is one of the areas seeing the largest reduction in U.S. troops. The U.S. started reducing forces from a peak of nearly 103,000 last year, and plans to have 68,000 troops by October.

Many Afghans and international observers have expressed concerns that the Taliban will try to re-impose strict Islamic justice as international forces withdraw. Under the Taliban, all music and film was banned as un-Islamic, and women were barred from leaving their homes without a male family member as an escort.

The Taliban spokesman for southern Afghanistan could not be reached for comment on the beheadings.

But a Taliban spokesman Qari Yousuf, who denied the group was involved. "I spoke to our commanders in those villages, but they know nothing of the event," he told Reuters.

In June, Taliban fighters stomed a lakeside hotel near Kabul demanding to know where the "prostitutes and pimps" were during a party, witnesses said. Twenty people were killed.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/ZNx5EePeesg/Did-Taliban-behead-17-people-for-dancing-Maybe-not

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Best Cheap Android Phones for Sale at WholesaleOnePiece - Buy ...

It is no doubt that everyone needs a best cheap android phone because it is such an important gadget in order to communicate with friends, relatives the modern society. Phones have becomes such an integral part of our life that we find our communications and other activities getting affected if we did not have them. They have gone beyond just being a communication device, they are also used for entertainment and communication.Currently the Android phones have taken the market by a storm. The need to have a smart phone today has become more than a luxury but a necessity for most people across the globe. This could be as a result of improved technology as most people today are computer literate and therefore the need for smart computers.
The Google owned Android software technology serves as the operating system behind a number of the latest cell phones. Though these phones are often viewed as competition for Apple's iPhone, this technology is actually the platform for Smartphones, currently serving over 400 million customers . Chinese cheap android phones are very interesting because of their versatile features and varied functionality. You can find some of the most sophisticated features that are available in top notch brands in these cell phones, yet they are priced at such a low rate that you won't feel like looking elsewhere to buy one for yourself.
Low end Androids use low end CPUs. Android doesn't like low end CPUs. iOS and Symbian generally work well on low end hardware but Android will lag like crazy making the experience very frustrating. As of this writing dual core 1.6ghz CPUs with GPU assist are the norm for new android phones 2012 whereas cheap Android phones will generally have a single core CPU running at less than 1ghz with no GPU.These devices also come with less RAM which means more frequent app crashes and swapping. They will also come with less storage space which as anyone who uses Android can attest to is incredibly frustrating as apps need to be constantly uninstalled and moved to and from external storage.
Android cell phones have the most advanced functionality, offering users the benefit of entertainment, educational, and functional applications that gives a totally different experience. Most of the android applications available in the market are free of cost which makes them all the more attractive for users. These mobile phones have been designed to make tasks easier which make them very efficient devices for those seeking a sophisticated communication and networking device hat also offers various multimedia functions. Interesting add-on feature available for these phones include Bluetooth, WI-Fi, Camera, and so on.The main reason why people prefer to buy an android cell phone over ordinary phones is because they offer the benefit of multi-tasking and multi-functionality. They are also designed to be very user friendly which makes them popular amongst others in the market.
To be attached online these days you require a portable and reliable gadget along with not only that home PC. With the demand in the economy, people have thus considered those cheap gadgets that can take care of their personal problems. Google is an American online conqueror with many people nowadays employing either their programs or employing their operating system cooperation with china store retail stores suppliers,Android operating system and other important apps have recently hit the market with a bang. You can purchase it from an online store that sells best android phone 2012 withort outgoing. These sites often provide special discounts that further reduce costs, thus making these cell phones an attractive buy.
Related android phones posts:
1. If Google cannot protect Android device Makers, perhaps Microsoft can
2. iPhone 5 release date: New Apple iPhone 5 accessories will be presented soon
3. iPhone 5 release Sept. 21: that's why Verizon has a vacation ban?
4. Rumour: iPhone 5, iPad mini launch events to be held separately?
5. A LOOK AT CHINESE CHEAP ANDROID TABLET MARKET

Source: http://androidphone.skyrock.com/3110800805-Best-Cheap-Android-Phones-for-Sale-at-WholesaleOnePiece.html

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Learn The Tips And Tricks Of Internet Marketing - Total Vibration

Would you like to develop the attain of your enterprise and gain far more revenue? Online marketing could be the way to attain these desired goals proficiently. Via Internet marketing, you can increase your sales by reaching clients by putting ads on numerous kinds of sites. This short article will enable you to leverage the numerous options online marketing gives.

Use persuasive words within your e-mails to consumers, encouraging these to require a specific motion. Purchasing services, browsing websites or subscribing to a particular periodicals are a few ways in which your customers may be involved. What is important is with an activity you?d like these people to take. By doing this, you are able to examine the strength of your email promotion by examining the speed of answer.

A way to succeed in Web marketing is knowing your competitors. Understand what they may be providing when compared with what you really are offering, and make the superior top quality and value of your products apparent. This really is required for any marketing campaign.

Developing a mailing list for the customers to sign up for is extremely important. You may provide clients the option to offer their info, or ensure it is mandatory for buys. In either case, you can use this details in the future to transmit out sales info, supply promo materials or to ask for customer comments.

Create a PR page that you enterprise could use as a feasible marketing plan. You put in content which a newspaper or on-line newspaper could use to label your web site. It?s quite simple for you to do also it can support get the company in the open.

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Discounting rates with affiliate marketing shops could be a strategy to gain a denser subscriber base. Try connecting various different markets. Doing this will boost all round sales. One example on this business design is definitely the online a reservation agent, who negotiates pricing for anyone booking a motel, automobile and air carrier solution concurrently. This plan is most effective with companies that have the same potential audience, but various goods.

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Website marketing demands severe investigation to be able to be successful. Get ideas in the people who have been successful prior to deciding to. Most of these men and women will also give you advice for the charge. Another important consideration is always to select an established approach, and ensure you abide by it. Do not forget that at first it will likely be sluggish, however it is worth every penny in the end.

Buyer followup is essential. Also, send out them a survey to submit as soon as they have gotten time to experience your product.

A great advice for increased online marketing procedures that many webmasters fail to understand is to make your web site basic however efficient. Exciting media like Adobe Flash may be appealing when making your web site, and web site developers may possibly make an effort to persuade one to use it. You want your web site being dynamic, however you also would like it to be offered to anyone. A properly made web site that promotes company realizes a method to be completely functional, even minus the most up-to-date sparkling and showy features.

You are fully competent at using a profitable website marketing enterprise at the moment. As an alternative to pricey computer software or fast-cash systems, you simply need to make use of your progressive mind. Accomplishment could be noticed by way of work and sensible marketing and advertising selections.

The knowledge you may have received by reading this article report ought to supply you with a head start on the net marketing and advertising rivalry. Ideally this information has offered you some very nice concepts you may incorporate in your advertising attempts. Utilizing the advice which you have discovered must bring about your experiencing greater income.

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Source: http://blog.thorsrubberhammer.com/2012/08/learn-the-tips-and-tricks-of-internet-marketing-10/

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Friday, August 24, 2012

The Curator: Startup Risk, Emerging Markets, Things Entrepreneurs ...

August 24, 2012

The Curator

Here?s our weekly link roundup of small business buzz, musings and muchness. A curation of the best small business talk around the web.

The Top 5 Risks Confronting Startups. ?You might have a great idea for a startup. You may be passionate, driven, and ready to go. But how ready are you to manage your risks?? (Xconomy)

A Kickstarter for Emerging Market Entrepreneurs. ?Traditional microfinance has not done enough to advance economic opportunities for the world?s poorest communities.? (The Huffington Post)

Overly Optimistic Things Entrepreneurs Say. ?It takes a special kind of person to be an entrepreneur. An entrepreneur exudes confidence and is by nature highly motivated. The results can be inspiring, producing some of the greatest inventions and innovations that improve our lives every day. But sometimes, the unique qualities that drive greatness can lead to some interesting behaviors?? (AllThingsD)

Why Venture Capital No Longer Defines Innovation. ?Today?s venture capital deal flow to innovative new companies looks a lot like a fat man trying to squeeze into a slim Italian suit. It just doesn?t fit. The new shape of innovation is a lot more inclusive of new approaches and sources of startup funding.? (ReadWriteWeb)

Startups Shouldn?t Ignore International Patent Protection. ?The tech giants are clearly at patent war ? Nokia vs. Google, Apple?s lawsuits in China, and Facebook vs. Yahoo!, etc. And international patent protection is clearly a vital part of both these companies? defensive and offensive competitive strategies. However, not much is said about how international patent protection does or should factor into the business strategies of startups.? (TechCrunch)

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Source: http://yfsentrepreneur.com/2012/08/24/the-curator-startup-risk-emerging-markets-things-entrepreneurs-say-venture-capital-patents/

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Thursday, August 23, 2012

Five things Brock Lesnar can still conquer

Five things Brock Lesnar has yet to accomplish

Well, Brock Lesnar did it. He beat Triple H at SummerSlam just like he said he would, made him tap just like Paul Heyman promised and, now, just like that, poof. Lesnar?s gone again.

He quit, actually, via a venomous Tout to the WWE Universe, Board of Directors and locker room that was recorded and uploaded on Monday night during Raw, only an hour or so after Heyman?s gloating victory speech to the WWE Universe. In the 15-second manifesto, the self-styled ?wrecking machine? claimed he had ?nothing left to conquer? within the confines of WWE following his savaging of Triple H at the summer classic, and declared he was leaving the squared circle, never to return.

Well, at the risk of our own physical well-being and the litigious proclivities of Heyman, we politely say: au contraire, dear Brock.

True, Lesnar has racked up innumerable victories during his brief, two-part career, holding the Undisputed Championship, being crowned King of the Ring and emerging victorious in the Royal Rumble Match. There?s admittedly not a whole lot that Lesnar hasn?t accomplished, but we here at WWE.com racked our brains and thought up a few mountains left for the big man to summit. For example:

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Source: http://www.wwe.com/shows/raw/2012-08-20/five-things-brock-has-yet-to-accomplish

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Parenting, Parenting Book How To Parent Together

ArticlesOnTap.com Teams Up With Single Parenting Advice Site To Manage Content Needs

ArticlesOnTap.com has just given word that it is teaming up with Single Parent Center, a noted web based resource offering quality single parenting advice on a variety of topics crucial to those raising children on their own in today's world.(PRWEB) August 22, 2012 Well established content management and consulting firm ArticlesOnTap.com has just given word that it is teaming up with Single ...

Lessons from The Netherlands - Every Child Counts

A culture of respect for children and a social consensus about the importance of parenting are among the cultural and policy settings that deliver excellent child outcomes in the Netherlands, according to The Netherlands Study , to be launched by Every Child Counts* on Wednesday.

Helicopter parenting can cause anxiety in kids

London, August 21 (ANI): "Helicopter" parenting, whereby mothers and fathers "hover" over their child, monitoring their safety and progress, could be making them more anxious and lacking in confidence as they get older, a new study claims.

The Practicing Parent debuts on Pronews 7

Pronews 7's Lisa Schmidt introduces her new segment for parents.

Breastfeeding dad wins support from parenting community

Breastfeeding advocates and parenting gurus are voicing support for a transgender Winnipeg man who nurses his infant son.

Book Review: Soul to Soul Parenting: A Guide to Raising a Spiritually Conscious Family by Annie Burnside

Book Review: Soul to Soul Parenting: A Guide to Raising a Spiritually Conscious Family by Annie Burnside Seattle Post-Intelligencer Copyright 2012 Seattle Post-Intelligencer. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. Published 2:54?p.m., Friday, August 17, 2012 The reader will be moved to be more nurturing to others after reading this ...

SheKnows Launches AllParenting, a New Social and Content-Driven Parenting Website Designed for Women, Not Just Moms

SheKnows proudly announces its newest addition to the family, AllParenting.com, a brand new parenting website driven by the desire to support and empower moms as not only parents, but also as women.

Parenting expert says abuser deserved jail

Parenting educator Dame Lesley Max says a judge got it wrong by not jailing a teenage dad who broke his baby's legs five times.Hastings man James Robert Hall, now 20, pleaded guilty to causing grievous bodily harm to his baby daughter...

Source of conflict: Study finds factors that can shape divorced mothers' co-parenting experiences

( Kansas State University ) The type of relationship a woman has with her ex-partner is a factor in how the couple shares custody of children, according to a Kansas State University expert on postdivorce and co-parenting relationships.

Mother Is Best? Why ?Intensive Parenting? Makes Moms More Depressed

In today?s parenting climate, having kids is not for the faint of heart. Parents, especially moms, are pelted with advice and recommendations: a ?good? mom stimulates her children constantly, taking them to museums and signing them up for character-broadening extracurricular activities. She reads all the current literature on parenting. And she takes primary responsibility for [...]

Source: http://ecommerce.matrix-e.com/eshops/143-parenting/23398-parenting-parenting-book-how-to-parent-together.html

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Build your cognitive skills with ThinkO for iPhone and iPad

Build your cognitive skills with ThinkO for iPhone and iPad

ThinkO for iPhone and iPad is a mind challenging puzzle game that focuses on your cognitive skills. The goal is simple: to move the rows and columns of rings to match the same colored squares. The challenging part is that every time you make a move, more squares start appearing, so if you aren't efficient with your choices, you will trap yourself with too many squares.

Concentration, problem solving, processing speed and memory are all required for being successful at playing ThinkO. As the game evolves, the levels become more challenging, requiring more sophisticated thinking skills. For example, as you play the game, large rings will appear in the levels. The rings are a bit of a hindrance because each one takes up the space of four squares, thus requiring you to move the two rows or columns containing it at a time. To get rid of a ring, you must make a sufficient amount of matches that are the same color as the ring.

In addition to the above mentioned rings, ThinkO also has special rings that will help you in the game. They become available as you progress and can also be purchased as in app purchased. Here's a list of the different rings available:

  • Rainbow rings are viral and contaminate adjacent ones
  • Diamond rings remove an entire block
  • Poison rings turn everything into green
  • Thunder rings eliminate all blocks in their path
  • Diamond rain drops single diamond rings everywhere

Although I haven't yet progressed very far in the game, I am really enjoying ThinkO. Puzzle games are my favorite because they require you to think, and ThinkO is no exception! ThinkO is definitely a great time-waster, but don't think of it as waste of time to play it -- by playing ThinkO, you are exercising your brain and improving your thinking skills!

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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/1g5DgLjO680/story01.htm

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Wednesday, August 22, 2012

Interesting Ideas And Highlights About Cosmetic Surgery | Health ...

You must know what you?re getting yourself into in order to be satisfied with the outcome of your surgery. By having background knowledge, you will be educated and well-informed enough to make smart decisions regarding your procedure. Read on to learn about what you need to know for a positive outcome.

Once you make the decision to have a cosmetic surgery procedure, there is a great deal of research for you to do and many things for you to learn. Be certain you don?t forget about the money! Make sure you include additional fees linked to your recovery, or a possible second procedure in case the results of the first one do not satisfy you. Don?t forget about the after-care costs, as well.

It is important to ensure you have extra money saved before having any cosmetic procedure done. If the procedure takes longer than anticipated, you may have to pay more money. Despite being unfair, you will be responsible for any and all charges incurred.

Ask your surgeon how many times he has done a successful surgery prior to the operation. Do not be shy about asking this because you do not want someone who has only done a few procedures before cutting into you. ?Practice makes perfect? applies greatly to surgeons and their abilities.

Take the time to explore different options before turning to surgery. Surgery can be financially, emotionally and physically costly. If you feel surgery is the best choice for you, be sure you have done the proper research to select the right surgeon.

Talk to the doctor thoroughly about any work you want done, and ask how many of the procedures they have performed. It is important to know how experienced your surgeon is. Carefully study photos of the procedures he or she has performed. Although there is no step you can take to guarantee a trouble-free procedure, verifying your surgeon?s expertise can really improve your odds in this respect.

Never be scared to ask questions about cosmetic surgery. You can ask your doctor to explain any medical terms that you do not understand. Ask the surgeon to repeat himself using normal language, and repeat back anything the surgeon says to confirm you understand.

Only consider a board certified plastic surgeon. You need to ask for proof of how many times your surgeon has performed this procedure.

Following rhinoplasty, it can be useful to run a humidifier while sleeping. If you use this method with some nose spray, you will heal quicker. It may even reduce the amount of recovery time a little bit. Be sure to talk with your surgeon about this ahead of the procedure.

The younger you are when you undergo plastic surgery, the easier it will be on you. As you get older, it becomes more difficult to rebound from invasive procedures. Surgeons believe that results are better for patients that undergo the procedure at earlier ages.

Increased self-esteem is one of the advantages of getting cosmetic surgery. People who have gone though a major injury, like a burn, can really benefit from it. After a person suffers from serious burns, they no longer feel like themselves. Because of this, cosmetic surgery is used to improve the appearance and self-esteem of the patient.

Armed with the information in this piece, you should now grasp the importance of knowledge when it comes to undergoing any cosmetic procedure. Use the tips you just read to help yourself have the best cosmetic surgery experience possible

Source: http://healthandfitnesstoday.blog.volksfreund.de/2012/08/21/interesting-ideas-and-highlights-about-cosmetic-surgery/

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Shares slip after Japan exports fall, euro steady

TOKYO (Reuters) - Asian shares slipped on Wednesday as slumping Japanese exports reminded investors of the risks the euro zone debt crisis poses to regional economies.

The euro held steady on expectations the European Central Bank will act to rein in surging borrowing costs. But a rise in the CBOE Volatility Index, a gauge of Wall Street's sensitivity to risk, and a pause in the recent run-up in U.S. Treasury yields suggested investors were yet to be convinced that Europe's three-year crisis is close to resolution.

"The recent rally in riskier assets had been built on a lull in Europe, so they are ready to face a correction when hopes for something unrealistic fade," said Takeo Okuhara, a fund manager at Daiwa SB Investments. He was referring to speculation that the ECB would buy bonds to cap the yields of troubled euro zone sovereigns.

"Economic data confirmed fundamentals are not strong, with a slowdown in China, which relies heavily on exports to Europe, having material effects elsewhere," he said.

European markets were seen falling, with financial spreadbetters calling London's FTSE 100, Paris's CAC-40 and Frankfurt's DAX to open down as much as 0.8 percent.

MSCI's broadest index of Asia-Pacific shares outside Japan fell 0.5 percent, led by sharp declines in the energy and materials sectors.

Japan's Nikkei stock average dipped 0.3 percent as investors cashed in gains from a sharp run-up on mounting hopes for ECB action, just as U.S. stocks fell on Tuesday after the Standard & Poor's 500 index hit a four-year high.

Japan's exports fell an annual 8.1 percent in July, the deepest drop in six months, dragged down by collapsing shipments to Europe and a sharp fall in sales to China. The fragile report from the world's third-biggest economy followed similarly bleak data from export-reliant South Korea and Taiwan.

Oil traded in ranges, capped by growth worries but supported by ECB hopes. Brent was up 0.1 percent to $114.77 a barrel and U.S. crude also inched up 0.1 percent to $96.94. Copper was down 0.2 percent to $7,595 a tonne ahead of earnings from top global miner BHP Billiton, which may put three mega projects on hold on Wednesday when it will likely report its first annual profit fall in three years.

BHP will wrap up a torrid earnings season for the world's biggest miners, all battered by weaker prices for iron ore, copper, coal, nickel and aluminium as economic growth in big-buyer China slows to its weakest pace in a decade.

Also limiting the downside is some view that Asian equities are not yet overbought. Flows of foreign capital remain important direction-setters for many Asian markets.

Net foreign buying stood at $8.1 billion so far in August, Credit Suisse said in a research note, below an overbought level.

Such purchases on a rolling 12-month basis is 0.6 percent of market capitalisation, below the 1 percent level seen overbought, Credit Suisse said, while net foreign buying over two months stands at 0.26 percent, less than the 0.6 percent or more seen as overheated.

ECB SPECULATION DIES HARD

Speculation that the ECB will take a decisive step to cut borrowing costs for Spain and Italy gained further momentum with an article in London's Daily Telegraph, that said the ECB was examining plans to put a hard cap on Spanish and Italian yields.

A similar report in German media was on Monday denied by the bank, which repeated its stance in response to the latest British report.

Meanwhile, German Chancellor Angela Merkel voiced support for the ECB's crisis-fighting strategy last week.

Greek Prime Minister Antonis Samaras is holding bilateral talks with leaders of France, Germany and the Eurogroup this week to seek concessions for its austerity-to-bailout swap.

"The market rallied on growing convictions that Germany stands ready to do more to keep the euro zone united. Merkel's government seems more willing to ease the official debt burden on Greece, as long as the basic elements of the second bailout programme remain," Barclays Capital said in a research note.

Spain's 10-year debt yields have shed about 8 percent this month on growing hopes for concrete action.

The euro traded at $1.2466, not far from $1.2488 hit on Tuesday, its highest since July 5.

Spot gold steadied around $1,638.66 an ounce, near a 3-1/2 month high of $1,641.20 touched on Tuesday.

Asian credit markets were weaker, pushing the spread on the iTraxx Asia ex-Japan investment-grade index by two basis points.

Source: http://news.yahoo.com/shares-slip-japan-exports-fall-euro-steady-054712087--finance.html

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Missouri congressman fights to save GOP Senate bid

ST. LOUIS (AP) ? Rep. Todd Akin fought to salvage his Senate campaign Monday, even as members of his own party turned against him and a key source of campaign funding was cut off in outrage over the Missouri congressman's comments that women are able to prevent pregnancies in cases of "legitimate rape."

Akin made no public appearances but went on former Republican presidential candidate Mike Huckabee's national radio show to apologize. He vowed to continue his bid for higher office.

"The good people of Missouri nominated me, and I'm not a quitter," Akin said. "To quote my old friend John Paul Jones, I have not yet begun to fight."

But Akin seemed to be losing political support by the hour as fellow Republicans urged him to abandon a race the party had long considered essential in their bid to regain control of the Senate. Incumbent Democrat Claire McCaskill is seen as vulnerable in public opinion polls and because she has been a close ally of President Barack Obama.

An official with the National Republican Senatorial Campaign Committee said the group's head, Texas Sen. John Cornyn, called Akin on Monday to tell him that the committee had withdrawn $5 million in advertising planned for the Missouri race. The official spoke to The Associated Press on condition of anonymity because the conversation was private.

At least one outside group that has pounded McCaskill with ads, the Karl Rove-backed Crossroads organization, also pulled its ads from Missouri.

Publicly, Cornyn called Akin's comments "indefensible" and suggested he take 24 hours to consider "what is best for him, his family, the Republican Party and the values that he cares about and has fought for."

The Senate's top Republican, Mitch McConnell of Kentucky, said Akin's remarks about rape may "prevent him from effectively representing" the Republican Party.

Two other Republican senators ? Scott Brown of Massachusetts and Ron Johnson of Wisconsin ? urged Akin to step aside from the Senate race.

Brown, who is locked in a tight race with Democrat Elizabeth Warren, said Akin's comments were "outrageous, inappropriate and wrong."

Johnson called Akin's statements "reprehensible and inexcusable," and urged Akin to withdraw "so Missouri Republicans can put forth a candidate that can win in November."

Akin also got a swift rebuke from the campaign of presumptive GOP presidential nominee Mitt Romney and his running mate, Rep. Paul Ryan of Wisconsin.

Romney and Ryan "disagree with Mr. Akin's statement, and a Romney-Ryan administration would not oppose abortion in instances of rape," Romney spokeswoman Amanda Henneberg said.

"Like millions of other Americans, we found them to be offensive," Romney said in an interview with National Review Online.

The furor began Sunday in an interview on KTVI-TV in St. Louis. Asked if he would support abortions for women who have been raped, Akin said: "It seems to me, first of all, from what I understand from doctors, that's really rare. If it's a legitimate rape, the female body has ways to try to shut that whole thing down."

Later Sunday, Akin released a statement saying that he "misspoke." But the fallout was swift and severe.

During the somber interview on Huckabee's program, Akin apologized repeatedly, saying he made "serious mistakes" in his comments on KTVI.

"Rape is never legitimate. It's an evil act. It's committed by violent predators," Akin said. "I used the wrong words the wrong way." He later made a similar apology in an appearance on Sean Hannity's radio show.

President Barack Obama said Akin's comments underscore why politicians ? most of whom are men ? should not make health decisions on behalf of women.

"Rape is rape," Obama said. And the idea of distinguishing among types of rape "doesn't make sense to the American people and certainly doesn't make sense to me."

The American Congress of Obstetricians and Gynecologists said a woman who is raped "has no control over ovulation, fertilization or implantation of a fertilized egg. ... To suggest otherwise contradicts basic biological truths."

Between 10,000 and 15,000 abortions occur each year nationwide among women whose pregnancies resulted from rape or incest. An unknown number of babies are born to rape victims, the group said.

Research on the prevalence of rape-related pregnancies is spotty. One estimate published in 1996 said about 5 percent of rapes result in pregnancy, or about 32,000 pregnancies among adult women each year.

McCaskill was ready to move on, saying Akin should not be forced out of the race.

"What's startling to me is that (Republican) party bigwigs are coming down on him and saying that he needs to kick sand in the face of all the primary voters," McCaskill said Monday at a campaign event in suburban St. Louis.

"I want Missourians to make a choice in this election based on policy, not backroom politics."

The McCaskill campaign seemed to favor a matchup against Akin. McCaskill ran statewide TV ads during the primaries painting Akin as too conservative even for Missouri. She also ran ads against his GOP rivals.

The Akin ads served two purposes for McCaskill: boosting Akin among the more conservative Republican primary voters to help get him nominated and raising questions about him among moderates and liberals.

Akin won the state's Republican Senate primary just two weeks ago by a comfortable margin over millionaire businessman John Brunner and former state Treasurer Sarah Steelman. Many considered him a favorite to beat McCaskill in November.

Experts say the rape comments were a game-changer.

"He may in fact have mortally wounded himself," said David Yepsen, director of the Paul Simon Public Policy Institute at Southern Illinois University in Carbondale. "This is a statement that is so crude and so offensive to more than half the electorate that there's a real danger here that he has dealt himself out of this race."

University of Missouri political scientist Peverill Squire said Akin's comments could particularly hurt him among suburban voters, where Republicans have done well in recent elections and "where McCaskill really does need to pick up some votes to stay in office. This certainly gives her an opening."

Ushering Akin from the race is complicated by the fact that he has never been a candidate beholden to the party establishment. Since being elected to Congress in 2000, Akin has relied on a grassroots network of supporters. His Senate campaign is being run by his son.

Missouri election law allows candidates to withdraw 11 weeks before Election Day. That means the deadline for the Nov. 6 election would be 5 p.m. Tuesday. Otherwise, a court order would be needed to remove a candidate's name from the ballot.

If Akin were to leave, state law gives the Republican state committee two weeks to name a replacement. The candidate would be required to file within 28 days of Akin's exit.

If Akin gets out, attention turns to Brunner and Steelman, but other possibilities include Missouri Auditor Tom Schweich, whom Republicans unsuccessfully tried to draft into the race earlier this year; former Sen. Jim Talent; and two members of Missouri's House delegation, Blaine Luetkemeyer and Jo Ann Emerson.

Talent, who lost his seat to McCaskill in 2006, said he would not enter the race, The Washington Post reported.

Akin, a former state lawmaker who was first elected to the House in 2000, has a long-established base among evangelical Christians. He has been an outspoken abortion opponent, and his campaign website proudly points out that he is listed among Planned Parenthood's "Toxic Ten" legislators.

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Associated Press writers Henry Jackson in Washington; Jim Suhr in St. Louis; Chris Blank in Jefferson City, Mo.; and Lindsey Tanner in Chicago contributed to this report.

Source: http://news.yahoo.com/missouri-congressman-fights-save-gop-senate-bid-211004078.html

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